NSAID Overdose: Signs, Risks, and What to Do Immediately

When you take too much of a common painkiller like NSAID, a class of nonsteroidal anti-inflammatory drugs used to reduce pain, fever, and inflammation. Also known as nonsteroidal anti-inflammatory drugs, they include ibuprofen, naproxen, and aspirin—medications millions use daily without issue. But when taken in excess, NSAID overdose can cause serious harm, even if you don’t feel sick right away.

NSAID overdose isn’t always obvious. You might think, "I just took a few extra pills," but the damage builds silently. These drugs strain your kidneys, irritate your stomach lining, and disrupt your blood’s ability to clot. In severe cases, they can trigger internal bleeding, acute kidney failure, or even seizures. The risk goes up if you’re older, have existing kidney or heart problems, or take them with other meds like blood thinners or antidepressants. Ibuprofen, a widely available NSAID often taken for headaches or muscle pain is one of the most common culprits in overdose cases—especially in teens and older adults who mistake it for harmless. Naproxen, a longer-acting NSAID often prescribed for arthritis stays in your system longer, so even a small overdose can have delayed but serious effects.

What should you do if you suspect an overdose? Don’t wait for symptoms. Call poison control or go to the ER—even if you feel fine. Early treatment can prevent organ damage. Doctors may give activated charcoal, IV fluids, or medications to protect your stomach and kidneys. There’s no single antidote, but quick action saves lives. Many of the posts below detail how to spot hidden dangers in everyday meds, how to read medication guides for overdose warnings, and what to do when a drug you thought was safe turns risky. You’ll find real stories from people who misjudged dosing, caregivers who caught errors in time, and experts explaining how even "over-the-counter" drugs carry serious risks when used without care. This isn’t about fear—it’s about knowing the line between help and harm.

NSAID Overdose: How to Recognize and Prevent Gastrointestinal Bleeding
Mark Jones 7 December 2025 11 Comments

NSAID Overdose: How to Recognize and Prevent Gastrointestinal Bleeding

NSAID overdose can cause silent, life-threatening gastrointestinal bleeding-even without pain. Learn who’s at risk, how to spot hidden bleeding, and what to do to protect yourself.